The Cannabis Sativa Plant.
Super-Critical Fluid (SCF) Processing.
Cannabidiol (CBD).
The cannabinoids are part of a relatively rare group of molecules known as the biphenyls. In the case of cannabinol (CBN), which has been shown to possess significant activity as peripheral analgesics(Wong and Cairns 2019) the biphenyl is linked further by a pyran system. Currently we use about 40,000 tons of biphenyls produced from petroleum for the control of fungi, bacteria and hypertension. An important value of hemp is that it allows use to replace these petroleum based products with renewable plant based materials. Cannabidiol (CBD) contains a reduced from of a biphenyl system in which one ring is not yet aromatized. Thus far there have been about 150 cannabinoids reported and about 500 phytochemicals in total characterized to date from Cannabis or hemp. To date there are 27,995 publication in PubMed.gov describing the chemistry, biology and pharmacology of the cannabinoids, with a large share of these focused on CBD.
CBD And Pain
CBD And Inflammation
References:
- Elkins, A. C., M. A. Deseo, S. Rochfort, V. Ezernieks and G. Spangenberg (2019). “Development of a validated method for the qualitative and quantitative analysis of cannabinoids in plant biomass and medicinal cannabis resin extracts obtained by super-critical fluid extraction.” J Chromatogr B Analyt Technol Biomed Life Sci 1109: 76-83.
- Philpott, H. T., M. OʼBrien and J. J. McDougall (2017). “Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.” Pain 158(12): 2442-2451.
- Romero-Sandoval, E. A., A. L. Kolano and P. A. Alvarado-Vázquez (2017). “Cannabis and Cannabinoids for Chronic Pain.” Curr Rheumatol Rep 19(11): 67.
- Wong, H. and B. E. Cairns (2019). “Cannabidiol, cannabinol and their combinations act as peripheral analgesics in a rat model of myofascial pain.” Arch Oral Biol 104: 33-39.
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